Keywords
drug resistance
drug development
mycobacterial cell wall
How to Cite
Abstract
Tuberculosis (TB) caused by Mycobacterium tuberculosis is an infectious disease. Control of TB is complicated by difficulties in the long-course chemotherapy treatment, the inability to eliminate latent microbes, and the increasing emergence of Multidrug Resistant (MDR) strains of M. tuberculosis. New anti-TB drugs are urgently needed, including developments of short-term treatments to minimize the emergence of drug resistance and new drugs to treat multidrug resistant tuberculosis and to eliminate the latent microbes. Many new structural anti-TB agents exhibited promising activities against susceptible and resistant strains of M. tuberculosis. The diarylquinoline with superior anti-tuberculotic activity and encouraging results of nitroimidazopyrans and oxazolidinones have generated considerable excitement.
References
Asif, M., Study of clinically used and recently developed antimycobacterial agents. Orient Pharm Exp Med 2012, 12, 15-34.
http://dx.doi.org/10.1007/s13596-011-0020-8
Zhang, Y.; Post-Martens, K.; Denkin, S., New drug candidates and therapeutic targets for tuberculosis therapy. Drug Discov Today 2006, 11, 21-27.
http://dx.doi.org/10.1016/S1359-6446(05)03626-3
Hasan, S.; Daugelat, S.; Rao, P. S.; Schreiber, M., Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2006, 2, e61.
http://dx.doi.org/10.1371/journal.pcbi.0020061
Zhang, Y., Persistent and dormant tubercle bacilli and latent tuberculosis. Front Biosci 2004, 9, 1136-1156.
http://dx.doi.org/10.2741/1291
Dye, C., Global epidemiology of tuberculosis. Lancet 2006, 367, 938-940.
http://dx.doi.org/10.1016/S0140-6736(06)68384-0
Asif, M., Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring. Med Chem 2012, 2, 151-167.
Blumberg, H.; Burman, W.; Chaisson, R.; Daley, C.; Etkind, S.; Friedman, L.; Fujiwara, P.; Grzemska, M.; Hopewell, P.; Iseman, M., American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Resp Crit Care Med 2003, 167, 603.
http://dx.doi.org/10.1164/rccm.167.4.603
Asif, M., Mini review on Ethmabutol and its some analogues as antitubercular agents. Elixir Pharm 2012, 53, 11774-11778.
Asif, M., Study of currently used antimycobacterials, their analogoues and recently developed agents. Indian Drugs 2012, 49, 5-19.
Zhang, Y.; Amzel, L., Tuberculosis drug targets. Curr Drug Targets 2002, 3, 131-154.
http://dx.doi.org/10.2174/1389450024605391
Asif, M.; Siddiqui, A. A.; Husain, A., Quinolone derivatives as antitubercular drugs. Med Chem Res 2013, 22, 1029-1042.
http://dx.doi.org/10.1007/s00044-012-0101-3
Asif, M., A review on potent antitubercular agent isoniazid and its Analogues. Int J Pharm Chem 2013, 2, 110-120.
http://dx.doi.org/10.7439/ijpc.v2i4.755
Eswaran, S.; Adhikari, A. V.; Ajay Kumar, R., New 1, 3-oxazolo [4, 5-c] quinoline derivatives: Synthesis and evaluation of antibacterial and antituberculosis properties. Eur J Med Chem 2010, 45, 957-966.
http://dx.doi.org/10.1016/j.ejmech.2009.11.036
http://dx.doi.org/10.1016/j.ejmech.2010.04.022
Eswaran, S.; Adhikari, A. V.; Chowdhury, I. H.; Pal, N. K.; Thomas, K., New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties. Eur J Med Chem 2010, 45, 3374-3383.
http://dx.doi.org/10.1016/j.ejmech.2009.11.036
http://dx.doi.org/10.1016/j.ejmech.2010.04.022
Gonalves, R. S.; Kaiser, C. R.; Lourenco, M.; de Souza, M. V.; Wardell, J. L.; Wardell, S. M.; da Silva, A. D., Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives. Eur J Med Chem 2010, 45, 6095-6100.
http://dx.doi.org/10.1016/j.ejmech.2010.09.024
Mao, J.; Yuan, H.; Wang, Y.; Wan, B.; Pak, D.; He, R.; Franzblau, S. G., Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs. Bioorg Med Chem Lett 2010, 20, 1263-1268.
http://dx.doi.org/10.1016/j.bmcl.2009.11.105
Kini, S. G.; Bhat, A. R.; Bryant, B.; Williamson, J. S.; Dayan, F. E., Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives. Eur J Med Chem 2009, 44, 492-500.
http://dx.doi.org/10.1016/j.ejmech.2008.04.013
Yang, C.-L.; Tseng, C.-H.; Chen, Y.-L.; Lu, C.-M.; Kao, C.-L.; Wu, M.-H.; Tzeng, C.-C., Identification of benzofuro [2, 3- b] quinoline derivatives as a new class of antituberculosis agents. Eur J Med Chem 2010, 45, 602-607.
http://dx.doi.org/10.1016/j.ejmech.2009.10.050
Wube, A. A.; Hfner, A.; Thomaschitz, C.; Blunder, M.; Kollroser, M.; Bauer, R.; Bucar, F., Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4 (1 H)-quinolones. Bioorg Med Chem 2011, 19, 567-579.
http://dx.doi.org/10.1016/j.bmc.2010.10.060
De Logu, A.; Palchykovska, L. H.; Kostina, V. H.; Sanna, A.; Meleddu, R.; Chisu, L.; Alexeeva, I. V.; Shved, A. D., Novel N-aryl-and N-heteryl phenazine-1-carboxamides as potential agents for the treatment of infections sustained by drug-resistant and multidrug-resistant Mycobacterium tuberculosis. Int J Antimicrob Ag 2009, 33, 223-229.
http://dx.doi.org/10.1016/j.ijantimicag.2008.09.016
Vicente, E.; Prez-Silanes, S.; Lima, L. M.; Ancizu, S.; Burguete, A.; Solano, B.; Villar, R.; Aldana, I.; Monge, A., Selective activity against Mycobacterium tuberculosis of new quinoxaline 1, 4-di- N-oxides. Bioorg Med Chem 2009, 17, 385-389.
http://dx.doi.org/10.1016/j.bmc.2008.10.086
Rao, S. S.; Raghunathan, R.; Ekambaram, R.; Raghunathan, M., In vitro activities of the newly synthesised ER-2 against clinical isolates of Mycobacterium tuberculosis susceptible or resistant to antituberculosis drugs. Int J Antimicrob Ag 2009, 34, 451-453.
http://dx.doi.org/10.1016/j.ijantimicag.2009.06.014
Turan-Zitouni, G.; zdemir, A.; Asim Kaplancikli, Z.; Benkli, K.; Chevallet, P.; Akalin, G., Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives. Eur J Med Chem 2008, 43, 981-985.
http://dx.doi.org/10.1016/j.ejmech.2007.07.001
Turan-Zitouni, G.; Kaplanc?kl?, Z. A.; zdemir, A., Synthesis and antituberculosis activity of some N-pyridyl- N?-thiazolylhydrazine derivatives. Eur J Med Chem 2010, 45, 2085-2088.
http://dx.doi.org/10.1016/j.ejmech.2010.01.017
Sankar, C.; Pandiarajan, K., Synthesis and anti-tubercular and antimicrobial activities of some 2r, 4 c-diaryl-3-azabicyclo [3.3. 1] nonan-9-one N-isonicotinoylhydrazone derivatives. Eur J Med Chem 2010, 45, 5480-5485.
http://dx.doi.org/10.1016/j.ejmech.2010.08.024
Bairwa, R.; Kakwani, M.; Tawari, N. R.; Lalchandani, J.; Ray, M. K.; Rajan, M. G. R.; Degani, M. S., Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents. Bioorg Med Chem Lett 2010, 20, 1623-1625.
http://dx.doi.org/10.1016/j.bmcl.2010.01.031
Correia, C.; Carvalho, M. A.; Proena, M. F., Synthesis and in vitro activity of 6-amino-2, 9-diarylpurines for Mycobacterium tuberculosis. Tetrahedron 2009, 65, 6903-6911.
http://dx.doi.org/10.1016/j.tet.2009.06.065
Khoje, A. D.; Kulendrn, A.; Charnock, C.; Wan, B.; Franzblau, S.; Gundersen, L.-L., Synthesis of non-purine analogs of 6-aryl-9-benzylpurines, and their antimycobacterial activities. Compounds modified in the imidazole ring. Bioorg Med Chem 2010, 18, 7274-7282.
http://dx.doi.org/10.1016/j.bmc.2010.08.016
Singh, K.; Singh, K.; Wan, B.; Franzblau, S.; Chibale, K.; Balzarini, J., Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity. Eur J Med Chem 2011, 46, 2290-2294.
http://dx.doi.org/10.1016/j.ejmech.2011.03.010
Gasse, C.; Douguet, D.; Huteau, V.; Marchal, G.; Munier-Lehmann, H.; Pochet, S., Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: Synthesis and in vitro anti-mycobacterial activity. Bioorg Med Chem 2008, 16, 6075-6085.
http://dx.doi.org/10.1016/j.bmc.2008.04.045
Odell, L. R.; Nilsson, M. T.; Gising, J.; Lagerlund, O.; Muthas, D.; Nordqvist, A.; Karln, A.; Larhed, M., Functionalized 3-amino-imidazo [1, 2-a] pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors. Bioorg Med Chem Lett 2009, 19, 4790-4793.
http://dx.doi.org/10.1016/j.bmcl.2009.06.045
Fassihi, A.; Azadpour, Z.; Delbari, N.; Saghaie, L.; Memarian, H. R.; Sabet, R.; Alborzi, A.; Miri, R.; Pourabbas, B.; Mardaneh, J.; Mousavi, P.; Moeinifard, B.; Sadeghi-aliabadi, H., Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides. Eur J Med Chem 2009, 44, 3253-3258.
http://dx.doi.org/10.1016/j.ejmech.2009.03.027
Mantu, D.; C?t?lina Luca, M.; Moldoveanu, C.; Zbancioc, G.; Mangalagiu, I. I., Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II. Eur J Med Chem 2010, 45, 5164-5168.
http://dx.doi.org/10.1016/j.ejmech.2010.08.029
Gzel, .; Karal?, N.; Salman, A., Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives. Bioorg Med Chem 2008, 16, 8976-8987.
http://dx.doi.org/10.1016/j.bmc.2008.08.050
Karal?, N.; Grsoy, A.; Kandemirli, F.; Shvets, N.; Kaynak, F. B.; zbey, S.; Kovalishyn, V.; Dimoglo, A., Synthesis and structureantituberculosis activity relationship of 1H-indole-2,3-dione derivatives. Bioorg Med Chem 2007, 15, 5888-5904.
http://dx.doi.org/10.1016/j.bmc.2007.05.063
Kamal, A.; Shetti, R. V. C. R. N. C.; Azeeza, S.; Ahmed, S. K.; Swapna, P.; Reddy, A. M.; Khan, I. A.; Sharma, S.; Abdullah, S. T., Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. Eur J Med Chem 2010, 45, 4545-4553.
http://dx.doi.org/10.1016/j.ejmech.2010.07.015
Termentzi, A.; Khouri, I.; Gaslonde, T.; Prado, S.; Saint-Joanis, B.; Bardou, F.; Amanatiadou, E. P.; Vizirianakis, I. S.; Kordulakova, J.; Jackson, M.; Brosch, R.; Janin, Y. L.; Daff, M.; Tillequin, F.; Michel, S., Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring. Eur J Med Chem 2010, 45, 5833-5847.
http://dx.doi.org/10.1016/j.ejmech.2010.09.048
Santos, J. L.; Yamasaki, P. R.; Chin, C. M.; Takashi, C. H.; Pavan, F. R.; Leite, C. Q. F., Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives. Bioorg Med Chem 2009, 17, 3795-3799.
http://dx.doi.org/10.1016/j.bmc.2009.04.042
Yoya, G. K.; Bedos-Belval, F.; Constant, P.; Duran, H.; Daff, M.; Baltas, M., Synthesis and evaluation of a novel series of pseudo-cinnamic derivatives as antituberculosis agents. Bioorg Med Chem Lett 2009, 19, 341-343.
http://dx.doi.org/10.1016/j.bmcl.2008.11.082
D'Oca, C. D. R. M.; Coelho, T.; Marinho, T. G.; Hack, C. R. L.; da Costa Duarte, R.; da Silva, P. A.; D'Oca, M. G. M., Synthesis and antituberculosis activity of new fatty acid amides. Bioorg Med Chem Lett 2010, 20, 5255-5257.
http://dx.doi.org/10.1016/j.bmcl.2010.06.149
Palomino, J. C.; Ramos, D. F.; da Silva, P. A., New anti-tuberculosis drugs: strategies, sources and new molecules. Curr Med Chem 2009, 16, 1898-1904.
http://dx.doi.org/10.2174/092986709788186066
Rivers, E. C.; Mancera, R. L., New anti-tuberculosis drugs in clinical trials with novel mechanisms of action. Drug Discov Today 2008, 13, 1090-1098.
http://dx.doi.org/10.1016/j.drudis.2008.09.004
Shi, R.; Sugawara, I., Development of new anti-tuberculosis drug candidates. Tohoku J Exp Med 2010, 221, 97-106.
http://dx.doi.org/10.1620/tjem.221.97
Asif, M., A review of antimycobacterial drugs in development. Mini Rev Med Chem 2012, 12, 1404-1418.
http://dx.doi.org/10.2174/13895575112091404
http://dx.doi.org/10.2174/138955712804586657
Janin, Y. L., Antituberculosis drugs: ten years of research. Bioorg Med Chem 2007, 15, 2479-2513.
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