Submissions

Research Articles

This section publishes full-length research manuscripts presenting novel findings in all areas of pharmaceutical chemistry. Submissions may report both positive and negative results, provided the work is based on rigorous experimental or theoretical design, with transparent methodology and appropriate reflection on the implications of the findings.

Topics include, but are not limited to, drug design and discovery, medicinal chemistry, pharmacokinetics, drug delivery systems, bioanalytical chemistry, natural product chemistry, synthetic methodologies, and chemical biology relevant to pharmaceutical sciences.

Research Reviews

This section publishes critical, comprehensive, and up-to-date overviews of important topics in pharmaceutical chemistry.

Reviews are primarily invited by the Editor, focusing on emerging specializations within the field, with the aim of increasing their visibility to the broader scientific community. In special circumstances, the Editor may also consider unsolicited review submissions, provided they fulfill the same criteria of addressing emerging domains and offering significant value to the readership.

Authors are expected to analyze and synthesize recent developments, including studies with both positive and negative outcomes—highlight current challenges, and identify future directions for research and application. Both narrative and systematic reviews, including meta-analyses, are welcome when aligned with the journal’s scope.

Research Communications

This section publishes concise reports of original work that present new and noteworthy findings in pharmaceutical chemistry. Preliminary results in emerging areas of research are welcome, provided they are well-documented and scientifically sound.

Submissions should be presented as Research Communications: concise manuscripts that highlight new findings which may help fellow researchers explore new directions, develop hypotheses, or refine methodologies. Both positive and negative outcomes are accepted, as long as they are clearly presented and thoughtfully interpreted.

Data Notes

This section publishes well-documented datasets that hold value for the pharmaceutical chemistry community and can be reused for further research, validation, or meta-analysis.

Submissions should include a clear description of the dataset, methods of generation, validation procedures, and potential applications. Raw data must be deposited in an accessible repository, with accession numbers or links provided.

Examples of suitable datasets include:

• Spectral Data Collections: NMR, MS, IR, or UV–Vis spectra of new compounds, metabolites, or drug derivatives.

• High-Throughput Screening Data: Bioactivity results from compound libraries or drug candidates tested against biological targets.

• Pharmacokinetic & Pharmacodynamic Data: Well-structured datasets on absorption, distribution, metabolism, excretion, and drug–drug interactions.

• Computational & Modeling Data: Docking results, QSAR models, molecular dynamics simulations, or virtual screening outcomes.

• Analytical Method Validation Data: Calibration curves, validation datasets, robustness/reproducibility data for pharmaceutical analysis.

• Formulation & Stability Data: Stability profiles, degradation kinetics, excipient compatibility studies.

• Natural Product Libraries: Chemical profiles, metabolomic datasets, or compound identification from natural sources relevant to drug discovery.

• Negative/Null Data Sets: Well-characterized experiments that demonstrate lack of activity, binding, or formulation stability, as these provide critical reference points for future research.

All datasets must be accompanied by sufficient metadata, methodological details, and a short explanatory narrative to ensure usability and proper citation by the scientific community.

Methodology/Technical Notes

This section publishes concise manuscripts describing the development, validation, or significant modification of experimental methods, analytical procedures, computational tools, or laboratory techniques relevant to pharmaceutical chemistry.

The emphasis is on how the work was done rather than the data output alone.

Suitable contributions may include:

• Novel synthetic routes or strategies for pharmaceutical compounds.

• Innovative analytical techniques for drug quality control, impurity profiling, or metabolite identification.

• Validation studies of bioanalytical methods (e.g., LC-MS/MS, HPLC, spectroscopy).

• Computational workflows such as QSAR models, molecular docking pipelines, or new algorithms for chemoinformatics.

• Improvements or adaptations of existing methods that enhance reproducibility, sensitivity, or efficiency.

• Comparative assessments of different techniques, including negative or null results that highlight methodological limitations.

Manuscripts should provide enough detail for reproducibility, including step-by-step protocols when applicable, validation data, and discussions of potential applications or limitations.

Case Studies

Case Reports / Case Studies

The Case Reports / Case Studies section provides a platform for publishing focused, practice-oriented contributions that highlight unusual, illustrative, or instructive applications of pharmaceutical chemistry. Unlike full-length research articles, case reports and case studies typically center on a single problem, challenge, or observation, and present it in sufficient detail to allow others to learn from the experience.

These contributions are intended to capture the kinds of findings, difficulties, or real-world applications that may not fit neatly into traditional research articles but nonetheless add significant value to the scientific and professional community.

Scope of Contributions

Submissions to this section may include, but are not limited to:

• Drug Formulation and Delivery Challenges: Case reports on unexpected formulation issues, solubility or stability concerns, bioavailability barriers, or excipient interactions, along with the strategies used to overcome them.

• Stability and Degradation Profiles: Reports of atypical degradation pathways, impurity formation, or stability failures under specific storage or environmental conditions.

• Analytical and Bioanalytical Case Studies: Accounts of unusual analytical challenges such as matrix effects, interference, or difficulties in compound quantification, and the solutions developed to address them.

• Synthetic and Medicinal Chemistry Cases: Descriptions of rare synthetic obstacles, low-yield reactions, or unexpected structure–activity relationships that provide insights for future drug discovery efforts.

• Industrial and Regulatory Case Studies: Experiences related to scale-up processes, manufacturing hurdles, regulatory compliance testing, or quality control issues that have broader implications for pharmaceutical development.

• Educational Case Studies: Real-world scenarios designed for teaching purposes, where pharmaceutical chemistry principles are applied in problem-based learning or laboratory training contexts.

Nature of Findings

Both positive and negative outcomes are welcome, provided they are:

• Well-documented with sufficient experimental or practical details.

• Critically interpreted to highlight the broader significance of the case.

• Contextualized within existing literature, showing how the case contributes to current knowledge.

Purpose and Value

Case Reports / Case Studies serve as a knowledge-sharing forum for highlighting the complexities and nuances of applying pharmaceutical chemistry principles in practice. By disseminating practical experiences, unusual observations, and problem-solving strategies, this section aims to:

• Provide guidance and lessons learned for researchers facing similar challenges.

• Stimulate innovation by drawing attention to overlooked or emerging problems.

• Bridge the gap between laboratory research, industrial application, and regulatory practice.

• Encourage transparency by reporting negative findings, failed attempts, or unexpected results that may prevent duplication of effort and guide future research.