#181 Role of natural phytoconstituent drug development against Nipah virus

Abstract

The Nipah virus, a paramyxovirus with Pteropus bats as its animal reservoir, was initially detected in a significant outbreak of severe encephalitis in Malaysia in 1998 among people who came into contact with ill pigs. Humans are already sensitive to the Nipah virus; many strains are capable of limited person-to-person transmission, and, as an RNA virus, it has an extraordinarily high rate of mutation. With the huge concern of the Nipah virus becoming another pandemic, and synthetic drugs are still incompatible and have major side effects, the emphasis on drug development using natural phytoconstituent’s can be a major boost to the healthcare system. In this abstract, the two phytoconstituent’s that are hydroxychavicol extracted from Piper beetle and mangiferin from mango was docked against the Nipah virus protein via AutoDock software as mentioned in the protein data bank, and it is observed that it shows good binding energy result and hence they can suggest that combined effect of both these phytoconstituent’s can be used for the treatment against Nipah virus. Hence it can be concluded that in the future, these phytoconstituents can be used as safe treatment options. However, further clinical evaluations are needed for more studies.