The present study is concerned with the formulation and optimization of famotidine mucoadhesive tablets by using a central composite design. The concentrations of Cordia dichotoma dried mucilage powder (X1) and PVP (X2) were selected as independent variables. In-vitro mucoadhesion time and percentage drug release were selected as dependent variables. The model was found to be nonlinear and the curvature effect was significant. Hence, the study reported to central composite design. Tablets were prepared by wet granulation method and all the tablets prepared were evaluated for post-compression parameters. FT-IR and DSC studies demonstrated that there is no interaction between drugs and excipients. All formulations showed mucoadhesion time of 5-9 h and drug release of 96.4% to 99.69%. The results of multiple linear regression analysis were showed that a decrease in the amount of X1(CDT) and an increase in the number of X2(PVP) leads to an increase in mucoadhesion time. Contour plots were exploited to judge the association between independent variables and dependent variables. The results demonstrated the effectiveness of the proposed design for the development of famotidine mucoadhesive tablets.
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