Helicobacter Pylori (H. pylori) is a common bacterium it causes gastritis and peptic ulcer disease. It affects half of the world’s population. The purpose of the research work has been to develop levofloxacin hemihydrate-loaded mucoadhesive alginate beads to treat H. pylori infection. Formulations were prepared by ion gelation method using various concentrations of sodium alginate, carbapol 974P, and calcium chloride. The compatibility studies, percentage yield, particle size, muco-adhesiveness, surface morphology, and invitro drug release studies were evaluated. The percentage yield for levofloxacin hemihydrate-loaded microspheres was found to be in the range of 35.2±1.37% to 89.18±0.821%. The drug to polymer ratio, the entrapment, loading, and encapsulation was found to range between 79.47±0.22 to 93.1±0.62%, 36.78±0.15 to 54.48±0.25%, and 68.11±0.19 to 84.9 ±0.57%, respectively. The mucoadhesive alginate beads were spherical, discrete, and compact, and size distribution was between 4 to 24 µm. In-vitro studies showed that the drug release became more uniform in its kinetic approach towards zero order. Regards, it showed a non-Fickian diffusion mechanism. The in vitro muco-adhesiveness study revealed that all the batches of prepared beads had good mucoadhesive properties. Accelerated stability studies show no remarkable changes were observed for the best formulation. The prepared mucoadhesive alginate beads of levofloxacin hemihydrate may prolong the gastric residence time and ensure high local drug concentrations, leading to improved H. pylori treatment.
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