More than 80% of peptic ulcer diseases are caused by H. pylori infection. The purpose of the study was to formulate and evaluate the floating microspheres of Levofloxacin hemihydrate to treat H.pylori infection. The floating microspheres of Levofloxacin hemihydrate were prepared by emulsion solvent diffusion technique using HPMC K100M, EC used as polymers. SEM, drug entrapment efficiency characterized the formulation; In-vitro Buoyancy Studies performed up to 12 h. In-vitro drug release and accelerated stability studies. The mean diameter of the microspheres was found to be in the range of 191.1–214 µm. The drug entrapment efficiency of the prepared microspheres varied from 49.35% to 69.25%. The percentage of buoyancy for this system was 74.61±1.4. The In-vitro buoyancy studies showed that most microspheres floated for around 9 h. In-vitro drug release achieved 80% in 12 h. Accelerated stability studies showed that formulation was stable. The prepared floating microspheres of Levofloxacin hemihydrate formulation, the drug-loaded microspheres had high floating time, and prolonged-release may provide more availability of the drug in the stomach. It may provide effective treatment against H. pylori.
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