Research Articles

X-ray crystal structure of N'-[(1E)-1-(2,4-dihydroxyphenyl)-ethylidene]pyridine-4-carbohydrazide

Vol. 6 No. 1 (2019) Published March 27, 2019

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Abstract

Schiff’s base of isonicotinyl hydrazide with 2’,4’-dihydroxy acetophenone (INH-RA) has been designed and synthesized as a part of library enumeration targeting the NS2B-NS3 protease of Dengue virus. Slow evaporation from methanol results in the formation of monoclinic crystals C2/c space group with eight molecules in the unit cell (a=20.0165(3) Å, b=7.7594(10) Å, c=19.4809(3) Å, α=90 °, β=111.368(1) °, γ=90 ° and Z=8).Three dimensional X-ray crystallographic structure of the compound has been determined and refined using SHELXS-97 and SHELXL-2014, respectively to a final R-value of 4.64%

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Jayaprakash, V.; Timiri, A. K.; Vijayan, V.; Sinha, B. N.; Devadasan, V. X-Ray Crystal Structure of N’-[(1E)-1-(2,4-Dihydroxyphenyl)-ethylidene]pyridine-4-Carbohydrazide. J Pharm Chem 2019, 6 (1). https://doi.org/10.14805/jphchem.2019.art108.
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Received
February 22, 2019
Published
March 27, 2019
Section
Research Articles

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Keywords

  • Schiff’s base
  • Isonicotinyl hydrazide
  • X-ray crystallography

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