Research Articles

Synthesis, Antiglycating and Antioxidant activities of Triazolo hexahydroquinazolines

Vol. 2 No. 2 (2015) 6-11 Published July 28, 2015

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Abstract

Some 5-aryl-triazolo[4,3-a] hexahydro quinazoline derivatives (4a-4e & 5a-5e) were synthesized and evaluated for their in vitro antiglycation and antioxidant activities. Title compounds were found to have potent antiglycating activity than rutin in the range between 0.096 and 0.300 M.The compounds 4b and 5c were the most active ones among them. The tested compounds had shown potent to moderate antioxidant activity by DPPH assay than BHT except 5e (p-NO2 phenyl derivative). Among all, hydroxyl derivatives (4a-4e) are more potent than the corresponding thiols (5a-5e).

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Author information

  • Umasankar Kulandaivelu

    Vaagdevi College of Pharmacy

  • Srikanth Challuri

    Vaagdevi College of Pharmacy

  • Rajasekhar Alavala Reddy

    Vaagdevi College of Pharmacy

  • Gomathi Periyasamy

    Vaagdevi College of Pharmacy

  • Shireesha Boyapati

    Vaagdevi College of Pharmacy

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Kulandaivelu, U.; Challuri, S.; Reddy, R. A.; Periyasamy, G.; Boyapati, S. Synthesis, Antiglycating and Antioxidant Activities of Triazolo Hexahydroquinazolines. J Pharm Chem 2015, 2 (2), 6-11. https://doi.org/10.14805/jphchem.2015.art30.
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Received
November 14, 2014
Published
July 28, 2015
Section
Research Articles
Pages
6-11

Keywords

  • Hexahydroquinazolines
  • Triazole
  • Antiglycating agents
  • Antioxidant agents

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