Issue

Vol. 3 No. 2 (2016)

Published April 30, 2016 2 articles

Research Articles

Evaluation of Antioxidant, Antimicrobial and Anticancer activity of Thiazole Tagged Isatin Hydrazones

Venkateshwarlu Eggadi, Umasankar Kulandaivelu, Sharvana Bhava Bandaru Sheshagiri, Venkateshwar Rao Jupalli

Isatin and its derivatives is versatile lead molecule for potential bioactive agents and shows wide spectrum of activities. In this study, we evaluated antioxidant, antimicrobial and cytotoxic activity of isatin-3-[N 2 -(2-benzalaminothiazol-4-yl)] hydrazone derivatives using well defined models. Antioxidant activity of the isatin derivatives ( Va - Vj ) was evaluated by using the 1, 1-diphenyl-2-picryl hydrazine radicals scavenging assay. The antimicrobial activity is evaluated by cup plate method and anticancer activity is evaluated by MTT assay against HBL-100 & HeLa cell lines. Compound Vh (R = 5-Cl, R 1  = OH & R 2  = OCH 3 ) showed good antioxidant activity with the IC 50  of 8.09 M. In addition  Ve  and  Vi  have showned most active antibacterial activity against  Bacillus subtilis ,  Staphylococcus aureus  and  Escherichia coli  with a Zone of Inhibition (mm) 20, 16, 18 and 14, 12, 15 on respective organism at 100 g/disc. The compound Vi have produced a good antifungal activity against  Aspergillus niger  and  Clostridium vericulata  with the zone of inhibition values of 9 and 8 mm respectively. These isatin derivatives also among the test compounds, compound  Vd  (R = 5-Cl, R 1  = OH & R 2  = OCH 3 ) and compound  Vh  (R = 5-Cl, R 1  = OH & R 2  = OCH 3 ) have shown nearly equal cytotoxic activity with IC 50  values of 246.53 mM and 247.29 mM against HBL-100 cell lines and HeLa cell lines respectively. From the results, isatin derivatives showed powerful antioxidant activity, antimicrobial and anticancer activity may be due to the halogens substituted at 5 th  position of isatin. The standard drugs used were ampicillin, clotrimazole, cisplatin and ascorbic acid for antibacterial, antifungal, anticancer and antioxidant respectively.

4-9

PDF

Research Reviews

The updates on Middle East Respiratory Syndrome coronavirus (MERS-CoV) epidemiology, pathogenesis, viral genome and currently available drugs

Surender Singh Jadav, Narayana Murthy Ganta, Anoop Kumar, Nirnoy Dan, Neha Padma Mohanty

The Middle East Respiratory Syndrome (MERS) is caused by the novel coronavirus belongs to the family Betacoronaviridae was first identified in Saudi Arabia during 2012. The first epidemic outbreak of the MERS-CoV has been started reporting in the South Korea and other Asian Countries. The disease was transmitted to humans to humans from the Middle East to other countries through travelling history. The MERS-CoV is responsible for the lower acute and severe respiratory disorder causes the shortness of breath along with fever and cough. The treatment for the disease is purely symptomatic and vaccination is not existed. In the present work we are tried to compile the epidemiology, pathogenesis, viral genome and currently available drugs. At the last the promising approaches for the drug design and development process has been presented.

10-18

PDF