Synthesis, Antiglycating and Antioxidant activities of Triazolo hexahydroquinazolines
Some 5-aryl-triazolo[ 4,3-a ] hexahydro quinazoline derivatives ( 4a-4e & 5a-5e) were synthesized and evaluated for their in vitro antiglycation and antioxidant activities. Title compounds were found to have potent antiglycating activity than rutin in the range between 0.096 and 0.300 M.The compounds 4b and 5c  were the most active ones among them. The tested compounds had shown potent to moderate antioxidant activity by DPPH assay than BHT except 5e ( p- NO 2  phenyl derivative). Among all, hydroxyl derivatives ( 4a-4e)  are more potent than the corresponding thiols ( 5a-5e ).
