Antitubercular drugs: advances in nitrogen containing heterocyclic compounds and some other derivatives


drug resistance
drug development
mycobacterial cell wall

How to Cite

Asif, M. Antitubercular Drugs: Advances in Nitrogen Containing Heterocyclic Compounds and Some Other Derivatives. J Pharm Chem 2014, 1 (2), 37-43.


Tuberculosis (TB) caused by Mycobacterium tuberculosis is an infectious disease. Control of TB is complicated by difficulties in the long-course chemotherapy treatment, the inability to eliminate latent microbes, and the increasing emergence of Multidrug Resistant (MDR) strains of M. tuberculosis. New anti-TB drugs are urgently needed, including developments of short-term treatments to minimize the emergence of drug resistance and new drugs to treat multidrug resistant tuberculosis and to eliminate the latent microbes. Many new structural anti-TB agents exhibited promising activities against susceptible and resistant strains of M. tuberculosis. The diarylquinoline with superior anti-tuberculotic activity and encouraging results of nitroimidazopyrans and oxazolidinones have generated considerable excitement.



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