PDF

Keywords

Tuberculosis
drug resistance
drug development
mycobacterial cell wall

How to Cite

(1)
Asif, M. Antitubercular Drugs: Advances in Nitrogen Containing Heterocyclic Compounds and Some Other Derivatives. J Pharm Chem 2014, 1, 37-43.

Abstract

Tuberculosis (TB) caused by Mycobacterium tuberculosis is an infectious disease. Control of TB is complicated by difficulties in the long-course chemotherapy treatment, the inability to eliminate latent microbes, and the increasing emergence of Multidrug Resistant (MDR) strains of M. tuberculosis. New anti-TB drugs are urgently needed, including developments of short-term treatments to minimize the emergence of drug resistance and new drugs to treat multidrug resistant tuberculosis and to eliminate the latent microbes. Many new structural anti-TB agents exhibited promising activities against susceptible and resistant strains of M. tuberculosis. The diarylquinoline with superior anti-tuberculotic activity and encouraging results of nitroimidazopyrans and oxazolidinones have generated considerable excitement.

https://doi.org/10.14805/jphchem.2014.art15
PDF

References

Asif, M., Study of clinically used and recently developed antimycobacterial agents. Orient Pharm Exp Med 2012, 12, 15-34.

http://dx.doi.org/10.1007/s13596-011-0020-8

Zhang, Y.; Post-Martens, K.; Denkin, S., New drug candidates and therapeutic targets for tuberculosis therapy. Drug Discov Today 2006, 11, 21-27.

http://dx.doi.org/10.1016/S1359-6446(05)03626-3

Hasan, S.; Daugelat, S.; Rao, P. S.; Schreiber, M., Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2006, 2, e61.

http://dx.doi.org/10.1371/journal.pcbi.0020061

Zhang, Y., Persistent and dormant tubercle bacilli and latent tuberculosis. Front Biosci 2004, 9, 1136-1156.

http://dx.doi.org/10.2741/1291

Dye, C., Global epidemiology of tuberculosis. Lancet 2006, 367, 938-940.

http://dx.doi.org/10.1016/S0140-6736(06)68384-0

Asif, M., Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring. Med Chem 2012, 2, 151-167.

Blumberg, H.; Burman, W.; Chaisson, R.; Daley, C.; Etkind, S.; Friedman, L.; Fujiwara, P.; Grzemska, M.; Hopewell, P.; Iseman, M., American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Resp Crit Care Med 2003, 167, 603.

http://dx.doi.org/10.1164/rccm.167.4.603

Asif, M., Mini review on Ethmabutol and its some analogues as antitubercular agents. Elixir Pharm 2012, 53, 11774-11778.

Asif, M., Study of currently used antimycobacterials, their analogoues and recently developed agents. Indian Drugs 2012, 49, 5-19.

Zhang, Y.; Amzel, L., Tuberculosis drug targets. Curr Drug Targets 2002, 3, 131-154.

http://dx.doi.org/10.2174/1389450024605391

Asif, M.; Siddiqui, A. A.; Husain, A., Quinolone derivatives as antitubercular drugs. Med Chem Res 2013, 22, 1029-1042.

http://dx.doi.org/10.1007/s00044-012-0101-3

Asif, M., A review on potent antitubercular agent isoniazid and its Analogues. Int J Pharm Chem 2013, 2, 110-120.

http://dx.doi.org/10.7439/ijpc.v2i4.755

Eswaran, S.; Adhikari, A. V.; Ajay Kumar, R., New 1, 3-oxazolo [4, 5-c] quinoline derivatives: Synthesis and evaluation of antibacterial and antituberculosis properties. Eur J Med Chem 2010, 45, 957-966.

http://dx.doi.org/10.1016/j.ejmech.2009.11.036

http://dx.doi.org/10.1016/j.ejmech.2010.04.022

Eswaran, S.; Adhikari, A. V.; Chowdhury, I. H.; Pal, N. K.; Thomas, K., New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties. Eur J Med Chem 2010, 45, 3374-3383.

http://dx.doi.org/10.1016/j.ejmech.2009.11.036

http://dx.doi.org/10.1016/j.ejmech.2010.04.022

Gonalves, R. S.; Kaiser, C. R.; Lourenco, M.; de Souza, M. V.; Wardell, J. L.; Wardell, S. M.; da Silva, A. D., Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives. Eur J Med Chem 2010, 45, 6095-6100.

http://dx.doi.org/10.1016/j.ejmech.2010.09.024

Mao, J.; Yuan, H.; Wang, Y.; Wan, B.; Pak, D.; He, R.; Franzblau, S. G., Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs. Bioorg Med Chem Lett 2010, 20, 1263-1268.

http://dx.doi.org/10.1016/j.bmcl.2009.11.105

Kini, S. G.; Bhat, A. R.; Bryant, B.; Williamson, J. S.; Dayan, F. E., Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives. Eur J Med Chem 2009, 44, 492-500.

http://dx.doi.org/10.1016/j.ejmech.2008.04.013

Yang, C.-L.; Tseng, C.-H.; Chen, Y.-L.; Lu, C.-M.; Kao, C.-L.; Wu, M.-H.; Tzeng, C.-C., Identification of benzofuro [2, 3- b] quinoline derivatives as a new class of antituberculosis agents. Eur J Med Chem 2010, 45, 602-607.

http://dx.doi.org/10.1016/j.ejmech.2009.10.050

Wube, A. A.; Hfner, A.; Thomaschitz, C.; Blunder, M.; Kollroser, M.; Bauer, R.; Bucar, F., Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4 (1 H)-quinolones. Bioorg Med Chem 2011, 19, 567-579.

http://dx.doi.org/10.1016/j.bmc.2010.10.060

De Logu, A.; Palchykovska, L. H.; Kostina, V. H.; Sanna, A.; Meleddu, R.; Chisu, L.; Alexeeva, I. V.; Shved, A. D., Novel N-aryl-and N-heteryl phenazine-1-carboxamides as potential agents for the treatment of infections sustained by drug-resistant and multidrug-resistant Mycobacterium tuberculosis. Int J Antimicrob Ag 2009, 33, 223-229.

http://dx.doi.org/10.1016/j.ijantimicag.2008.09.016

Vicente, E.; Prez-Silanes, S.; Lima, L. M.; Ancizu, S.; Burguete, A.; Solano, B.; Villar, R.; Aldana, I.; Monge, A., Selective activity against Mycobacterium tuberculosis of new quinoxaline 1, 4-di- N-oxides. Bioorg Med Chem 2009, 17, 385-389.

http://dx.doi.org/10.1016/j.bmc.2008.10.086

Rao, S. S.; Raghunathan, R.; Ekambaram, R.; Raghunathan, M., In vitro activities of the newly synthesised ER-2 against clinical isolates of Mycobacterium tuberculosis susceptible or resistant to antituberculosis drugs. Int J Antimicrob Ag 2009, 34, 451-453.

http://dx.doi.org/10.1016/j.ijantimicag.2009.06.014

Turan-Zitouni, G.; zdemir, A.; Asim Kaplancikli, Z.; Benkli, K.; Chevallet, P.; Akalin, G., Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives. Eur J Med Chem 2008, 43, 981-985.

http://dx.doi.org/10.1016/j.ejmech.2007.07.001

Turan-Zitouni, G.; Kaplanc?kl?, Z. A.; zdemir, A., Synthesis and antituberculosis activity of some N-pyridyl- N?-thiazolylhydrazine derivatives. Eur J Med Chem 2010, 45, 2085-2088.

http://dx.doi.org/10.1016/j.ejmech.2010.01.017

Sankar, C.; Pandiarajan, K., Synthesis and anti-tubercular and antimicrobial activities of some 2r, 4 c-diaryl-3-azabicyclo [3.3. 1] nonan-9-one N-isonicotinoylhydrazone derivatives. Eur J Med Chem 2010, 45, 5480-5485.

http://dx.doi.org/10.1016/j.ejmech.2010.08.024

Bairwa, R.; Kakwani, M.; Tawari, N. R.; Lalchandani, J.; Ray, M. K.; Rajan, M. G. R.; Degani, M. S., Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents. Bioorg Med Chem Lett 2010, 20, 1623-1625.

http://dx.doi.org/10.1016/j.bmcl.2010.01.031

Correia, C.; Carvalho, M. A.; Proena, M. F., Synthesis and in vitro activity of 6-amino-2, 9-diarylpurines for Mycobacterium tuberculosis. Tetrahedron 2009, 65, 6903-6911.

http://dx.doi.org/10.1016/j.tet.2009.06.065

Khoje, A. D.; Kulendrn, A.; Charnock, C.; Wan, B.; Franzblau, S.; Gundersen, L.-L., Synthesis of non-purine analogs of 6-aryl-9-benzylpurines, and their antimycobacterial activities. Compounds modified in the imidazole ring. Bioorg Med Chem 2010, 18, 7274-7282.

http://dx.doi.org/10.1016/j.bmc.2010.08.016

Singh, K.; Singh, K.; Wan, B.; Franzblau, S.; Chibale, K.; Balzarini, J., Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity. Eur J Med Chem 2011, 46, 2290-2294.

http://dx.doi.org/10.1016/j.ejmech.2011.03.010

Gasse, C.; Douguet, D.; Huteau, V.; Marchal, G.; Munier-Lehmann, H.; Pochet, S., Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: Synthesis and in vitro anti-mycobacterial activity. Bioorg Med Chem 2008, 16, 6075-6085.

http://dx.doi.org/10.1016/j.bmc.2008.04.045

Odell, L. R.; Nilsson, M. T.; Gising, J.; Lagerlund, O.; Muthas, D.; Nordqvist, A.; Karln, A.; Larhed, M., Functionalized 3-amino-imidazo [1, 2-a] pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors. Bioorg Med Chem Lett 2009, 19, 4790-4793.

http://dx.doi.org/10.1016/j.bmcl.2009.06.045

Fassihi, A.; Azadpour, Z.; Delbari, N.; Saghaie, L.; Memarian, H. R.; Sabet, R.; Alborzi, A.; Miri, R.; Pourabbas, B.; Mardaneh, J.; Mousavi, P.; Moeinifard, B.; Sadeghi-aliabadi, H., Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides. Eur J Med Chem 2009, 44, 3253-3258.

http://dx.doi.org/10.1016/j.ejmech.2009.03.027

Mantu, D.; C?t?lina Luca, M.; Moldoveanu, C.; Zbancioc, G.; Mangalagiu, I. I., Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II. Eur J Med Chem 2010, 45, 5164-5168.

http://dx.doi.org/10.1016/j.ejmech.2010.08.029

Gzel, .; Karal?, N.; Salman, A., Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives. Bioorg Med Chem 2008, 16, 8976-8987.

http://dx.doi.org/10.1016/j.bmc.2008.08.050

Karal?, N.; Grsoy, A.; Kandemirli, F.; Shvets, N.; Kaynak, F. B.; zbey, S.; Kovalishyn, V.; Dimoglo, A., Synthesis and structureantituberculosis activity relationship of 1H-indole-2,3-dione derivatives. Bioorg Med Chem 2007, 15, 5888-5904.

http://dx.doi.org/10.1016/j.bmc.2007.05.063

Kamal, A.; Shetti, R. V. C. R. N. C.; Azeeza, S.; Ahmed, S. K.; Swapna, P.; Reddy, A. M.; Khan, I. A.; Sharma, S.; Abdullah, S. T., Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. Eur J Med Chem 2010, 45, 4545-4553.

http://dx.doi.org/10.1016/j.ejmech.2010.07.015

Termentzi, A.; Khouri, I.; Gaslonde, T.; Prado, S.; Saint-Joanis, B.; Bardou, F.; Amanatiadou, E. P.; Vizirianakis, I. S.; Kordulakova, J.; Jackson, M.; Brosch, R.; Janin, Y. L.; Daff, M.; Tillequin, F.; Michel, S., Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring. Eur J Med Chem 2010, 45, 5833-5847.

http://dx.doi.org/10.1016/j.ejmech.2010.09.048

Santos, J. L.; Yamasaki, P. R.; Chin, C. M.; Takashi, C. H.; Pavan, F. R.; Leite, C. Q. F., Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives. Bioorg Med Chem 2009, 17, 3795-3799.

http://dx.doi.org/10.1016/j.bmc.2009.04.042

Yoya, G. K.; Bedos-Belval, F.; Constant, P.; Duran, H.; Daff, M.; Baltas, M., Synthesis and evaluation of a novel series of pseudo-cinnamic derivatives as antituberculosis agents. Bioorg Med Chem Lett 2009, 19, 341-343.

http://dx.doi.org/10.1016/j.bmcl.2008.11.082

D'Oca, C. D. R. M.; Coelho, T.; Marinho, T. G.; Hack, C. R. L.; da Costa Duarte, R.; da Silva, P. A.; D'Oca, M. G. M., Synthesis and antituberculosis activity of new fatty acid amides. Bioorg Med Chem Lett 2010, 20, 5255-5257.

http://dx.doi.org/10.1016/j.bmcl.2010.06.149

Palomino, J. C.; Ramos, D. F.; da Silva, P. A., New anti-tuberculosis drugs: strategies, sources and new molecules. Curr Med Chem 2009, 16, 1898-1904.

http://dx.doi.org/10.2174/092986709788186066

Rivers, E. C.; Mancera, R. L., New anti-tuberculosis drugs in clinical trials with novel mechanisms of action. Drug Discov Today 2008, 13, 1090-1098.

http://dx.doi.org/10.1016/j.drudis.2008.09.004

Shi, R.; Sugawara, I., Development of new anti-tuberculosis drug candidates. Tohoku J Exp Med 2010, 221, 97-106.

http://dx.doi.org/10.1620/tjem.221.97

Asif, M., A review of antimycobacterial drugs in development. Mini Rev Med Chem 2012, 12, 1404-1418.

http://dx.doi.org/10.2174/13895575112091404

http://dx.doi.org/10.2174/138955712804586657

Janin, Y. L., Antituberculosis drugs: ten years of research. Bioorg Med Chem 2007, 15, 2479-2513.

http://dx.doi.org/10.1016/j.bmc.2007.01.030

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.