#168 An in silico approach to identify potential medicinal componds for anti-rheumatoid arthritis activity using polyherbal transdermal patch

Abstract

Herbal transdermal patches can develop valuable assessment and drug safety by additional site-specific the way and temporal position in the body’s imperative to reduce the number and size of doses required to achieve the objective of systemic medication during topical application to the intact skin surface. Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease of unknown cause. It is characterized by persistent inflammation that primarily affects the peripheral joints. Various treatments and management have been in progress on wide ranges. Molecular docking is a virtual screening method that cutback the expenses and time duration for the identification of pharmacophores from natural products. Polyherbal transdermal patch was developed by using ethanolic extracts of leaves of Cardiospermum halicacabum and rhizomes of Drynaria quercifolia. The developed polyherbal transdermal patch was subjected to Gas Chromatography-Mass Spectroscopy (GC-MS) for Identification of phytoconstituents. This in-silico study has been screen the phytochemical components binding with human Interleukin- 6 (IL-6) receptor by using AutoDock Vina software. The results obtained after docking showed a good binding affinity and implicated that the active phytoconstituents of the developed formulation would be a supportive measure for the treatment of Rheumatoid Arthritis