#215 Formulation and solubility analysis of amorphous solid dispersions of Diclofenac sodium: A comparative study

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Rathnanand, M. .; Shetty, B. .; Dhatri, D. .; Roychawdhury, R. #215 Formulation and Solubility Analysis of Amorphous Solid Dispersions of Diclofenac Sodium: A Comparative Study. J Pharm Chem 2022, 8.


Amorphous solid dispersions (ASDs) are aimed to improve the solubility of poorly water-soluble drugs. The purpose of the present study was to determine the technique which provided maximum solubility of ASD of Diclofenac sodium with suitable polymer and buffer media. ASDs can be prepared using various methods. In this experiment, ASDs of BCS Class 2 drug Diclofenac sodium were prepared using various methods like solvent evaporation with heat and without heat, rotary evaporation using Rota vapor, and Hot Melt Extrusion. Three different polymers HPMC, PVP, and Soluplus, were used in the preparation of ASDs. ASDs obtained were characterized using analytical techniques like FT-IR and DSC. Solubility study was conducted by dissolving the obtained ASDs in buffers with pH 1.2, 6.8, 7.4, and water. Samples were kept in Rotaspin for 48 h, later these were centrifuged, and the supernatant was analyzed using UV/Vis spectrophotometer. Graphs were plotted for data obtained from solubility analysis and were compared. When all data were compared, ASDs prepared using HME with three polymers showed improved solubility in pH 7.4 buffer and water. By this, we could conclude that HME was the best method to prepare ASDs of Diclofenac sodium.


da Silvaa TL, Vidarta JM, da Silva Jr AC, Gimenesb ML, Vieiraa MG, da Silva MG. (2015) Evaluation of Incorporation of Diclofenac Sodium in Dried Sericin-Alginate Particles Prepared by Ionic Gelation Technique. Chem Eng Trans 43:829-834. DOI: https://doi.org/10.3303/CET1543139

de Alencar Danda LJ, de Medeiros Batista L, Melo VC, Sobrinho JL, Soares MF. (2019) Combining amorphous solid dispersions for improved kinetic solubility of posaconazole simultaneously released from soluble PVP/VA64 and an insoluble ammonio methacrylate copolymer. Eur J Pharm Sci 133:79-85. DOI: https://doi.org/10.1016/j.ejps.2019.03.012

Van den Mooter G. (2012) The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate. Drug Discov Today Technol 9(2):e79-e85. DOI: https://doi.org/10.1016/j.ddtec.2011.10.002

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