#215 Formulation and solubility analysis of amorphous solid dispersions of Diclofenac sodium: A comparative study

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Rathnanand, M. .; Shetty, B. .; Dhatri, D. .; Roychawdhury, R. #215 Formulation and Solubility Analysis of Amorphous Solid Dispersions of Diclofenac Sodium: A Comparative Study. J Pharm Chem 2022, 8.

Abstract

Amorphous solid dispersions (ASDs) are aimed to improve the solubility of poorly water-soluble drugs. The purpose of the present study was to determine the technique which provided maximum solubility of ASD of Diclofenac sodium with suitable polymer and buffer media. ASDs can be prepared using various methods. In this experiment, ASDs of BCS Class 2 drug Diclofenac sodium were prepared using various methods like solvent evaporation with heat and without heat, rotary evaporation using Rota vapor, and Hot Melt Extrusion. Three different polymers HPMC, PVP, and Soluplus, were used in the preparation of ASDs. ASDs obtained were characterized using analytical techniques like FT-IR and DSC. Solubility study was conducted by dissolving the obtained ASDs in buffers with pH 1.2, 6.8, 7.4, and water. Samples were kept in Rotaspin for 48 h, later these were centrifuged, and the supernatant was analyzed using UV/Vis spectrophotometer. Graphs were plotted for data obtained from solubility analysis and were compared. When all data were compared, ASDs prepared using HME with three polymers showed improved solubility in pH 7.4 buffer and water. By this, we could conclude that HME was the best method to prepare ASDs of Diclofenac sodium.

References

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