#200 Formulation and evaluation of gastro-retentive tablet by using RAFT forming system

Abstract

The study was conducted to develop a gastro-retentive tablet of carvedilol by raft forming system for the treatment of hypertension. It was achieved by the formulation of carvedilol tablets using different polymers in variable ratios. The raft drug delivery provides drug delivery for more than eighteen hours by forming a gel-like structure. Preparation of gastro retentive tablet using raft forming system in wet granulation method. Ingredients mentioned carvedilol, sodium alginate, sodium bicarbonate, chitosan were used to prepare Carvedilol gastro retentive tablets. All ingredients except the binder and lubricant were mixed thoroughly and passed through sieve 80. PVP K30 was dissolved in a sufficient quantity of propranolol and added to a powder mixture to prepare dough wet mass. The prepared wet mass was passed through a 10 sieve. The granules were allowed to dry in a hot air oven at 70 °C for 1 h and then resifted through a 44 sieve. To the granule’s talc, and magnesium stearate were added. Granules were compressed to a tablet using an 8 mm diameter flat punch with the help of a rotary tablet compression machine. From the results of research work, it can be concluded that raft forming gastro retentive tablets of Carvedilol can be successfully prepared by wet granulation method by sodium alginate, chitosan, sodium bicarbonate. Among all the formulations, it is concluded that gastro retentive tablets prepared using chitosan (10%) by raft forming method gave better results due to increased gastric residence time and its absorption. Hence, this formulation will be helpful to achieve good bioavailability and better therapeutic activity. Prepared gastro-retentive tablets were evaluated for hardness, friability, weight variation, drug content, raft strength, acid neutralization capacity, in-vitro release study, and short-term stability studies. From all formulations containing sodium alginate 16%, sodium bicarbonate 7.5%, chitosan 10%, and sufficient concentration of tale and magnesium stearate was selected as optimized formulations, chitosan 10% show comparatively good release for 12 h.