#191 Evaluation of herbal extract(HC) for its activity against anticancer drug-induced bone marrow toxicity in Wistar rats

Abstract

Among all side effects seen, those associated with the effects of anticancer therapy on the bone marrow (BM) represent a potentially dangerous and even life-threatening circumstance. Because most anticancer treatments affect rapidly dividing cells preferentially, BM is an ideal target for these effects. This is the primary reason that myelosuppression is among the complications most frequently seen. Bone marrow is a complex organ responsible for the regulation of hematopoietic cell distribution throughout the human body. Myelosuppression is a common and anticipated adverse effect of cytotoxic chemotherapy. It is a potential but rare idiosyncratic effect with any other drug, but there is a recognized association with a number of higher-risk agents, which justify additional vigilance. Myelosuppression is potentially life-threatening because of the infection and bleeding complications of neutropenia and thrombocytopenia. The co-administration of bone marrow protecting or antioxidant herb with the Anti-cancer drug may reduce the drug-induced bone marrow toxicity. The present study aimed to explore the protective effect of RV forte capsules (resveratrol-based formulation) and TCCT (curcumin-based formulation) tablets for their protective potential against Cyclophosphamide-induced bone marrow toxicity in Wistar rats at the dose of 100 and 400 mg/kg dose. In this research work, RV forte TCCT tablets at 400 mg/kg dose showed a significant protective effect against Cyclophosphamide-induced bone marrow toxicity. Significant reduction in histological changes in bone marrow has been observed in treatment groups as compared to only Cyclophosphamide treated groups. Also, the oxidative stress parameters, SOD, CAT, MDA, were found to be reduced, signifying the protective effect of both formulations.