#188 Evaluation of herbal composite for its activity against anticancer drug induced hepatotoxicity in Wistar rats

Abstract

The liver plays a crucial role in the metabolic elimination of most drugs and other foreign compounds, thus making it an important target for toxicity. The hepatotoxic response is expressed in the characteristic form of cell death in specific zones of acinar regions in the liver. Keeping the above perspectives in mind, the herb, RV forte (resveratrol-based formulation) capsules, and TCCT (curcumin-based formulation) tablets traditionally used in the treatment of hepatotoxicity were selected, there is a need to explore the full potential of this combination as a hepatoprotective agent. The herbal composite consists of a combination of RV forte (resveratrol-based formulation) and TCCT (curcumin-based formulation) tablets. All the herbs used in the composite are proven to be safe and clinically used in many herbal formulations. The herbal composite is a unique combination of selected herbs and is proposed to be effective in minimizing the toxicities of anticancer therapy. In this study we found that in RV forte (resveratrol-based formulation) (C100 and C400): treated groups C400 dose showed more significant hepatoprotection as compared to C100 and in Resveratrol (R100 and R400) treated groups R400 dose showed more significant hepatoprotection as compared to R100. The RV forte (resveratrol-based formulation) at a dose of 400 mg/kg body weight showed more significant hepatoprotection against CTX induced hepatotoxicity as compared to all other treatment groups C100, R100, R400.