The aim here is to optimize and characterize the chitosan-coated nanoparticles of Forskolin and Rutin for ocular delivery for the treatment of glaucoma. Forskolin and Rutin nanoparticles coated with chitosan were prepared by the emulsion solvent evaporation method. A four-factor three-level Box-Behneken design was used to investigate the influence of independent variables on particle size and entrapment efficiency. Characterization was done for particle size, entrapment efficiency, and in-vitro drug release. The optimized nanoparticles showed particle size and entrapment efficiency of 135 nm and 74.09%, respectively. The in-vitro release study of both drugs (Forskolin and Rutin) showed a sustained release up to 24 h. Chitosan-coated nanoparticles of Forskolin and Rutin were successfully developed and optimized by Box-Bhekhen statistical design using chitosan, PLGA, and PVA as an independent variable. Nanoparticles were found to be spherical in shape 200 nm with positive zeta potential. The in-vitro release study shows a longer duration. In future, an in-vivo study will be performed to obtain the pharmacokinetic and pharmacodynamic study of the nanoparticles.
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