#175 Anti-obesity activity of Annona squamosa (Linn.) leaves extract on monosodium glutamate - High fat diet-induced obese mice model

The Methanolic extract of leaves of Annona squamosa (Linn.) has been tested for their anti-obesity property. The extracts were examined for the presence of phytoconstituents, antioxidant activity, digestive enzyme activity, hypoglycaemic effect, hypophagic effect & histology of adipose tissue, and fatty liver changes by using MSG-HFD induced obesity in Swiss albino mice. Animals treated with ASPE have reduced the increase in body weight, periepididymal fat weight, etc. The anti-obesity activity produced by ASPE may be because of inhibition of amylase enzyme, antioxidant activity, the presence of tannins, and flavonoid content. These findings suggest that the anti-obesity actions of ASPE may be partly mediated by delaying the intestinal absorption of dietary fat. The plants have shown the presence of essential phytoconstituents like sitosterols and stigmasterols in NMR, TLC, and HPTLC study whereas some common constituents like saponin, flavonoids, steroids, triterpenoids, glycosides, and anthocyanin were also present in the preliminary phytochemical study. In this study, ASPE is found to be beneficial for the suppression of obesity and some associated complications.