#155 Synthesis, characterization and molecular docking study of some quinoline based Schiff’s bases as potential Eg5 inhibitory agents

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Alegaon, S. .; U, V. .; Kavalapure, R. . #155 Synthesis, Characterization and Molecular Docking Study of Some Quinoline Based Schiff’s Bases As Potential Eg5 Inhibitory Agents. J Pharm Chem 2022, 8.

Abstract

In Search of novel Eg5 inhibitory agents, new series of quinoline-based Schiff bases molecules were designed, synthesized, and their structures were elucidated using FTIR, 1H-NMR, 13C-NMR, and mass spectral analysis. The newly synthesized compounds were evaluated for their Steady-state ATPase and Malachite Green Assays. The results of Malachite Green Assay revealed that compound 2((7-chloroquinolin-4-yl) amino)-N’-(4-formylbenzylidene) benzo hydrazide showed better inhibitory activity with IC50 Value of 0.095±0.27 µM and Steady-state ATPase results revealed that some compounds exhibited promising inhibitory activity (IC50 values of 2.408±0.46 to 2.720±0.69, 2.676±0.53 µM ). A molecular docking study was performed to evaluate interaction into the binding site of kinesin spindle protein; this interaction influencing may support Eg5 inhibitory activity. Some of the compounds in present analogs could be a promising lead for advanced Eg5 inhibitory agents’ discovery.

Fig. Design of Eg5 Inhibitors

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