#152 Design and characterisation of green tea catechin loaded biodegradable nanoparticles

Abstract

Catechins, an herbal polyphenolic flavonoid found in green tea, have received considerable attention due to their favorable biological properties, including cardioprotective, neuroprotective, and anti-cancer effects. The aim of the present work is to develop biodegradable polymeric nanoparticles based oral drug delivery for encapsulation and controlled release of polyphenol compound Catechin. Catechin nanoparticles were prepared using biodegradable polymer Poly-ε-Caprolactone (PCL) by Solvent Diffusion technique using TPP as cross-linking agent. SEM analysis showed that the nanoparticles were smooth and the average particle size of the optimized formulation is 218.7±0.579 nM. The Zeta potential showed incipient stability for the best formulation. FTIR and DSC showed no significant interactions between catechin and Poly-ε-Caprolactone after encapsulation and cross-linking. Results showed a substantial change in the release rate and in the percentage entrapment of Catechin from nanoparticles formulations. The percentage yield of all the nanoparticles showed a good yield. The highest drug entrapment efficiency (90.73%) and in-vitro release (91.87%) were obtained with the optimized formulation (CTC5). The prepared Catechin-loaded nanoparticles proved to be promising dosages form with improved bioavailability.