#127 Preparation and optimization of Tinidazole loaded transferosomal gel

Abstract

The aim of the present study is to formulate and optimize a tinidazole-loaded transfersomal gel. Transfersomes are formed by self-assembly of non-ionic surfactant and soya lecithin upon hydration with an aqueous medium resulting in a lamellar structure that encapsulates both polar and non-polar drugs. It is also a vesicular carrier for drug delivery systems. In the present research work, we prepared tinidazole transfersome using a non-ionic surfactant, span 60, and soya lecithin in a ratio of 80:20 concentration by the thin-film hydration method. These prepared tinidazole transfersomes were then incorporated into a gel which was prepared by varying concentrations of poloxamer 407. Evaluation of prepared transfersomal gels done by homogeneity, grittiness, spreadability, extrudability, drug content, in-vitro diffusion, and stability study. In this experiment performed transferosomal suspension was dispersed in carbomer and Poloxamer gel, a tinidazole transferosomal gel was created for Bacterial Vaginosis. After evaluation of both the gels, Tinidazole transfersomal gel having poloxamer as the gelling agent was found to have greater in-vitro drug release 90.41% along with the highest R2 value among all the formulations and good stability for shelf life. Tinidazole Transfersomal gel formulation provided sustained and prolonged delivery of Tinidazole in controlled manner with constant release as it follows zero-order release kinetics. The optimized formulation of transfersomal gel containing tinidazole is quite simple and stable.