#77 Design, synthesis and characterization of disubstituted metal complex compounds of 2-(1,3-dioxoisoindolin-2-yl) acetic acid derivatives as anti-inflammatory agents

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Dhabarde, D. . #77 Design, Synthesis and Characterization of Disubstituted Metal Complex Compounds of 2-(1,3-Dioxoisoindolin-2-Yl) Acetic Acid Derivatives As Anti-Inflammatory Agents. J Pharm Chem 2022, 8.

Abstract

The current investigation aimed to design, synthesize, and characterize novel anti-inflammatory drugs for superior action and reduce concomitant effects. Novel disubstituted metal complex compounds of 2-(1, 3-dioxoisoindolin-2-yl) acetic acid derivatives were designed, synthesized, characterized. The compounds were synthesized through amide intermediates. Virtual screening of synthesized compounds was checked by employing molecular docking against cyclooxygenase-II inhibitor (PDB ID: 4G7S). The compounds' structures were identified using spectral FT-IR and 1H-NMR Spectrophotometer. Anti-inflammatory activity was evaluated by applying the carrageenan-induced paw edema model in albino wistar rats. The synthesized compounds showed remarkable depletion of paw edema. The percent inhibition of edema of disubstituted metal complexes of cobalt and zinc produced good anti-inflammatory activity compared to the standard drug Diclofenac.

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