#61 Synthesis and biological evaluation of some novel 1, 3, 5-triaryl-2-pyrazolines derivatives

Abstract

In the present study, 3, 4-dichloroacetophenone on condensation with different aromatic aldehydes in aqueous ethanolic solution yield corresponding chalcones. These chalcones react with phenylhydrazine obtained,1, 3, 5-triaryl-2-pyrazoline derivatives. All the prepared compounds were characterized by IR, NMR spectral data, and elemental analysis. The synthesized compounds screened for various biological activities. The compound, 2o containing a 2”-thienyl ring present at the 5^th position of the pyrazoline scaffold showed good antifungal activity with MIC 2 µg/mL. The compound 2f and 2h containing 2”,4”-difluorophenyl and 4”-trifluorophenyl moieties at position-5 showed excellent antitubercular activity at MIC 1.6 μg/mL.