#47 Formulation development and evaluation of oral care herbal product from Azadiracta indicia

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A V, J. .; L K, D. S.; V, K. K. .; P S, N. . #47 Formulation Development and Evaluation of Oral Care Herbal Product from Azadiracta Indicia. J Pharm Chem 2022, 8.

Abstract

Azadiracta indicia is an herbal medicine which is used for various ailments. We have made efforts to bring a new formulation of toothpaste with more stable in terms of rheological behavior, long-term protection and stability in diverse conditions. The aim of the present study is the formulation of new herbal toothpaste and its evaluations along with stability studies. The plant Azadiracta indicia (Neem) is used for the preparation. Plant leaves and stems are separately extracted and used for the formulation. The four different formulations of three different concentrations of 0.25%, 0.50%, 0.75% were coded as Azadiracta indicia leaf extract (AILE), Azadiracta indicia stem extract (AISE), leaf paste (LP) & stem paste (SP) and are evaluated for the studies. The evaluation parameters are hard and sharp edges abrasive particles, spread ability in cm, pH, foaming power in mL and the stability tests of antimicrobial activity such as antibacterial & antifungal activities are done by cup plate method using Ciprofloxacin and Amphotericin B as standard drugs by taking the tests of different concentrations 250 µg, 500 µg, 750 µg, & 1000 µg are incubated at 280 °C for 24 h, the zone of inhibition is measured in mm by using bacterias (Klebsiella pneumonia, Escherichia coli, Staphylococcus aurous, Pseudomonas aeruginosa) and fungi (Candida albicans). The hard and sharp edges abrasive particles are absent in every formulation, spread ability is maximum in AILE (0.25%) than LP (0.25%), foam formation will increase with the increase in concentration in the case of extracts and decreases with increase in concentration in the case of powder formulations, pH is maximum for LP formulation in higher concentration (0.75%) and minimum for AILE at a lower concentration (0.25%) only. The stability studies of toothpaste is having a good zone of inhibition with comparing the standard drugs. The developed toothpaste could be utilized in the treatment of various periodontal diseases. Further pharmacological evaluations, toxicological studies, and possible isolation of the therapeutic antibacterial from this plant are future challenges.

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